Menopause is not a disease but a natural biological process that marks the end of menstruation and fertility in women. Even though it is a natural course of a woman’s life cycle, menopause causes physical and psychological symptoms that can disturb your sleep, drain your energy and evoke feelings of sadness. A variety of treatments have traditionally been available, including lifestyle changes and hormone therapy. The potential problems associated with taking hormone replacement therapy for menopausal symptoms have led to the search for non-hormonal treatment options. Antidepressant medicines, particularly the selective serotonin reuptake inhibitors or SSRIs such as sertraline, may be effective for treating some symptoms of menopause. Sertraline, sold under the brand name Zoloft, is an antidepressant medicine that affects chemicals in your brain that may become unbalanced and cause symptoms of depression, panic or anxiety. Preliminary scientific research has shown that sertraline may also have benefits in treating symptoms of menopause such as hot flashes. Your doctor can usually diagnose hot flashes based on a description of your symptoms. Your doctor might suggest blood tests to check whether you're in menopausal transition. The most effective way to relieve the discomfort of hot flashes is to take estrogen, but taking this hormone carries risks. If estrogen is appropriate for you and you start it within 10 years of your last menstrual period or before age 60, the benefits can be greater than the risks. Medications such as antidepressants and anti-seizure drugs also might help reduce hot flashes, although they're less effective than hormones. Discuss the pros and cons of various treatments with your doctor. If hot flashes don't interfere with your life, you probably don't need treatment.
Menopause. 2006 Jul-Aug;134568-75. Sertraline to treat hot flashes a randomized controlled, double-blind, crossover trial in a general population. Gordon. Skip Navigation Links Home 1997 - Volume 4 - Issue 4 P-29. Sertraline Zoloft for the Management of Hot Flashes. Previous Abstract · Next Abstract.