A blood pressure reading consists of two numbers (for example, 120/80). The top number is known as the systolic blood pressure, and the bottom number is the diastolic blood pressure. High blood pressure (hypertension) is defined as an average blood pressure higher than 140/90. In clinical studies, propranolol has been shown to significantly lower systolic and diastolic blood pressures. This site does not dispense medical advice or advice of any kind. The higher the dose of propranolol, the greater the drop in blood pressure is expected to be. Site users seeking medical advice about their specific situation should consult with their own physician. By lowering blood pressure, propranolol can decrease the risks that occur with long-term high blood pressure Inderal Tablet [package insert]. Propranolol Hydrochloride Injection [package insert]. Click In order for us to create your customized Health Savvy programs, we need a little more information about the health topic(s) that you are interested in. Philadelphia, PA: Wyeth Pharmaceuticals, Inc.;2007 December. Propranolol Hydrochloride Solution [package insert]. Press "Continue" button below to begin selecting your Health Savvy topic(s). Remember, you need at least one selected topic to use Health Savvy. Apo-Propranolol (CA), Bedranol SR (UK), Betachron E-R, Beta-Prograne (UK), Dom-Propranolol (CA), Half Beta-Prograne (UK), Half Inderal LA (UK), Inderal LA, Inno-pran XL, Novopranol (CA), Nu-Propranolol (CA), PMS Propranolol (CA), Rapranol SR (UK), Slo-Pro (UK), Syprol (UK) • In patients with angina pectoris, exacerbations of angina and, in some cases, myocardial infarction (MI) have followed abrupt drug withdrawal. Antacids (aluminum-based): decreased propranolol absorption Anticholinergics, tricyclic antidepressants: antagonism of cardiac beta-adrenergic blocking effect Chlorpromazine: additive hypotension Cimetidine: increased propranolol blood level and risk of toxicity Digoxin: additive bradycardia Diuretics, other antihypertensives: increased hypotensive effect Glucagon, isoproterenol: antagonism of propranolol's effects Insulin, oral hypoglycemics: impaired glucose tolerance, increased risk of hypoglycemia Neuromuscular blockers: increased neuromuscular blockade (with high propranolol doses) Nonsteroidal anti-inflammatory drugs: decreased hypotensive effect Theophylline: decreased theophylline clearance, antagonism of theophylline's bronchodilating effect Thioridazine: increased thioridazine blood level, leading to prolonged QT interval Drug-diagnostic tests. For planned withdrawal, reduce dosage gradually over at least a few weeks and caution patient not to interrupt or stop therapy without physician's advice. Alkaline phosphatase, blood urea nitrogen, eosinophils, lactate dehydrogenase, serum transaminases, triiodothyronine: increased levels Glucose: decreased or increased level Platelets, thyroxine: decreased levels Drug-behaviors. • Monitor CBC and liver and thyroid function tests. If therapy is interrupted and angina exacerbation occurs, consider reinstituting drug and taking other measures to manage unstable angina. dose directly into large vein or into tubing of compatible I. solution (dextrose 5% in water, normal or half-normal saline solution, or lactated Ringer's solution). Acute alcohol ingestion: additive hypotension • Monitor vital signs, ECG, and central venous pressure. • Watch closely for signs and symptoms of hypoglycemia, which drug may mask. As coronary artery disease may be unrecognized, it may be prudent to follow same advice in patients at risk for occult atherosclerotic heart disease who receive drug for other indications. If necessary, give second dose after 2 minutes and additional doses at intervals of no less than 4 hours until desired response occurs. use is usually reserved for arrhythmias that are life-threatening or occur during anesthesia. • Monitor blood glucose level in diabetic patient, to identify need for altered insulin or oral hypoglycemic dosage. • Tell patient to monitor pulse and to promptly report bradycardia or tachycardia. Life-threatening arrhythmias; arrhythmias occurring during anesthesia Adults: 1 to 3 mg slow I. • Hypersensitivity to drug, its components, or other beta-adrenergic blockers • Uncompensated heart failure • Cardiogenic shock • Sinus bradycardia, heart block greater than first degree • Bronchospastic disease Use cautiously in: • renal or hepatic impairment, sinus node dysfunction, pulmonary disease, diabetes mellitus, hyperthyroidism, Raynaud's syndrome, hypertensive emergencies, myasthenia gravis • concurrent thioridazine use • history of severe allergic reactions • elderly patients • pregnant or breastfeeding patients • children (safety not established). Be aware that in labile diabetes, hypoglycemia may be accompanied by steep blood pressure rise. • Inform patient that drug may cause muscle aches or bone pain. CNS: fatigue, asthenia, anxiety, dizziness, drowsiness, insomnia, memory loss, depression, mental status changes, nervousness, paresthesia, nightmares CV: peripheral vasoconstriction, orthostatic hypotension, bradycardia, arrhythmias, heart failure, myocardial infarction and sudden death (with abrupt withdrawal in angina therapy) EENT: blurred vision, dry eyes, nasal congestion, rhinitis, sore throat GI: nausea, vomiting, diarrhea, constipation, dry mouth GU: erectile dysfunction, decreased libido Hematologic: purpura, thrombocytopenic purpura Metabolic: fluid retention, hyperglycemia, hypoglycemia (increased in children), thyrotoxicosis (with abrupt withdrawal in hypertension therapy) Musculoskeletal: joint pain, back pain, myalgia, muscle cramps Respiratory: wheezing, bronchospasm, pulmonary edema Skin: pruritus, rash Other: fever Drug-drug. infusion, dilute with normal saline solution and infuse in 0.1- to 0.2-mg increments over 10 to 15 minutes.
Propranolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of stroke and heart attacks. Propranolol is also used to treat severe chest pain (angina), migraine headaches, or hypertrophic subaortic stenosis (thickened heart muscle). This medicine may also be used to treat irregular heartbeats, tremors, or pheochromocytoma (adrenal gland tumor). Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Propranolol is used to treat tremors, angina (chest pain), hypertension (high blood pressure), heart rhythm disorders, and other heart or circulatory conditions. It is also used to treat or prevent heart attack, and to reduce the severity and frequency of migraine headaches. Hemangeol (propranolol oral liquid 4.28 milligrams) is given to infants who are at least 5 weeks old to treat a genetic condition called infantile hemangiomas. Hemangiomas are caused by blood vessels grouping together in an abnormal way. These blood vessels form benign (non-cancerous) growths that can develop into ulcers or red marks on the skin. Hemangiomas can also cause more serious complications inside the body (in the liver, brain, or digestive system).
Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation blood flow through arteries and veins. Propranolol is used to treat tremors, angina chest pain, hypertension high blood pressure, heart rhythm disorders, and other heart or circulatory conditions. Propranolol hydrochloride is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80. Inderal is available as 10 mg, 20 mg, 40 mg, 60 mg, and 80 mg tablets for oral administration.