Jude Children's Research Hospital have demonstrated a more effective treatment for bacterial pneumonia following influenza. They found that the antibiotics clindamycin and azithromycin, which kill bacteria by inhibiting their protein synthesis, are more effective than a standard first-line treatment with the "beta-lactam" antibiotic ampicillin, which causes the bacteria to lyse, or burst. The finding is important because pneumonia, rather than the influenza itself, is a principal cause of death from influenza in children and the elderly. During pandemics--such as the one that may arise from avian influenza--up to 95 percent of influenza deaths are due to pneumonia. Jude Infectious Diseases department, expect the new findings, currently demonstrated in mice, to be incorporated into standard clinical practice guidelines during the next few years. A bioterrorism attack using the influenza virus would likely result in the same high percentage of pneumonia deaths, according to the researchers. Mc Cullers and his colleagues published their findings in the advanced, online issue of the Journal of Infectious Diseases. The researchers based the new treatment on growing evidence that beta-lactams are relatively ineffective against secondary pneumonia because the drugs exacerbate inflammation caused by influenza. "With severe secondary pneumonia, it has seemed that physicians do almost everything they can, and it doesn't work," Mc Cullers said. Winter is almost here, and a typical phone call to the pharmacy will likely involve questions about antibiotics to treat pneumonia. When doctors call, it is usually because the patient has multiple drug allergies and/or drug interactions that make antibiotic selection difficult. Based on Infectious Disease Society of America/American Thoracic Society guidelines, I have organized the information in a chart that makes sense to me. This chart is my sole creation, and I encourage others to formulate their own charts if they do not understand or like mine. I organized my chart from the least-aggressive drug regimen to the most aggressive. Once a bacterium is identified in the cultures, de-escalation occurs to avoid unnecessary adverse effects, costs, and possible drug resistance. What is significant for retail pharmacists is that the guidelines are for doxy or a macrolide but never both at the same time. If a prescription comes across for a z-pack and doxy, that would be a red flag to call the doctor.
Dec 5, 2017. care unit ICU, Ceftriaxone or unasyn plus azithromycin or quin. To treat serious cases of pneumonia, the guidelines are for a very high. Reviews and ratings for azithromycin when used in the treatment of pneumonia. 26 reviews submitted.