Propecia syndrome

Posted: gordon50 Date: 02-Feb-2019
Finasteride - Wikipedia

Finasteride - Wikipedia

When you were a teenager, did your mom or dad warn you about the dangers of smoking cigarettes—but you went ahead and tried it anyway? According to estimates, about 20% of people go on to become adult smokers; in 2016 the CDC reported that 15.5% of adults were smokers, down from 20.9% in 2005. Well, by now we all know that smoking cigarettes is the number one source of preventable death and disease, so it’s pretty hard to deny that the potential consequence are harsh. For men, two conditions can trouble the body and bruise the ego. The first, benign prostatic hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland that can lead to urinary problems: more frequent urination, getting up at night, difficulty starting urination, etc. The second, male pattern baldness, can occur due to gradual hormonal loss plus genetic factors; balding can impact a man’s self-image and his social activities if he feels less attractive or manly. A medication called Finasteride is prescribed for both conditions, though the dosage may differ. Finasteride is a class of drug called a 5-alpha reductase type II enzyme inhibitor. Two weeks ago, White House physician Ronny Jackson issued a highly anticipated statement on President Donald Trump’s health following a complete physical exam. Trump, Jackson claimed, is in “excellent health” with no concern of physical or cognitive decline. Jackson also revealed that, in addition to cholesterol medication and a multivitamin, the president pops the oral supplement finasteride (often sold as the brands Propecia, Propecia Pro-Pak, and Proscar) to treat male-pattern baldness. While the use of finasteride to help prevent male-pattern baldness is not new—it was first approved for treating prostate enlargement in 1992 before being rebranded and sold in 1997 as a hair-loss drug—it has come under fire in recent years for its supposed extreme side effects. In 2015, Merck, the drug’s manufacturer, was hit with multiple class-action lawsuits alleging the drug caused severe sexual and emotional side effects. Nikki Hill, a board-certified dermatologist and hair-loss specialist based in Tucker, Georgia, using finasteride in FDA-approved doses (1 milligram) is not harmful for the vast majority of her patients.“About 2 percent of men in their twenties have sexual side effects,” Hill told The Daily Beast. Occasionally, Hill’s patients will report decreased sperm volume after taking the drug and sometimes even bouts of depression—but that side effect is thankfully rare, Hill says. “I’ve had maybe three people in six years tell me that they feel a little more depressed, but they don’t know if it’s circumstantial or due to taking the medicine.

Nimmt ein Mann den Wirkstoff Finasterid ein, um Haarausfall entgegenzuwirken, besteht das Risiko, dass sich das negativ auf sein Liebesleben auswirkt: Erektionsstörungen, Libidoverlust und Ejakulationsstörungen können sogar nach dem Absetzen des Mittels anhalten, heißt es im Beipackzettel. Wie häufig diese Nebenwirkungen weiter bestehen bleiben, erfährt man jedoch nicht. Auch beim Wirkstoff Dutasterid, der Männern zur Behandlung einer Prostatavergrößerung verschrieben wird, wird darauf hingewiesen, dass Impotenz eine mögliche Nebenwirkung ist. Finasterid und Dutasterid greifen an derselben Stelle in den Stoffwechsel des Sexualhormons Testosteron ein. Ein internationales Forscherteam wollte genauer beziffern, wie oft die Probleme auftreten und wie stark die Dauer der Einnahme das Risiko beeinflusst. Die Wissenschaftler um Steven Belknap von der Northwestern University Feinberg School of Medicine in Chicago haben dafür Daten von rund 12.000 Männern ausgewertet, die einen der Wirkstoffe oder beide eingenommen haben und vorher nicht über sexuelle Probleme klagten. Unter anderem verglichen sie deren weitere Gesundheit mit der von Männern, denen keines der Mittel verschrieben wurde, wie sie im Fachmagazin "Peer J" berichten. Finasteride is a 5-alpha reductase type II enzyme inhibitor used to treat hair loss (eg, Propecia, Profal and Re Gen) or enlarged prostate (eg, Proscar, Finasteride Rex and Fintral). PFS includes sexual, physical, and mental and neurological symptoms in patients who have taken finasteride (Table 1). Symptoms often persist after the patient has stopped taking finasteride. Table 1: Reported symptoms of Post-Finasteride Syndrome Importantly, some patients can experience suicidal ideation and depression after stopping finasteride treatment. Patients and their families should be advised about these symptoms and to seek medical advice as soon as possible if they occur. Unfortunately, PFS is a condition with no known cure and few, if any, effective treatments. Further information about PFS can be found on the Post-Finasteride Syndrome Foundation website (

PDF FDA Petition to Remove Finasteride From United States Drug.
PDF FDA Petition to Remove Finasteride From United States Drug.

Mar 13, 2018. marketing approval for Propecia® Finasteride from the United States;. cause a debilitating condition known as Post-Finasteride Syndrome. Das Post-Finasterid-Syndrom PFS beschreibt einen von Ärzten, Patienten und Medien verwendeten Begriff für ein Symptomkomplex mit anhaltenden.

Propecia syndrome
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