Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Is hydroxychloroquine sulfate an immunosuppressive drug Chloroquine dose in child Shared care guidelines hydroxychloroquine Plaquenil superama After refusing methotrexate due to my fear of yet more unwelcome side effects, my rheumatologist convinced me to try Plaquenil. I started on 400mg March 2016. After a couple of weeks I developed a "rare" side effect of my ears ringing unbelievably loud. So loud it would keep me from sleeping, and wake me up at night when I did manage to sleep. Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx. This is a really good article. I am on Plaquenil and Methotrexate. We tried Enbrel for a year, then had to switch to Remicade. Still not working well, we have increased the dosage twice. I am on Prednisone 5mg just as a temporary measure until I go back next week. It is time to move on, but I couldn’t decide between Rituxin, Acterma, or Orencia. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. When to switch from plaquenil to methotrexate Common Questions About Taking Methotrexate for Rheumatoid., Methotrexate vs Plaquenil? - Hydroxychloroquine 12.5mgDo you still have flare ups while taking hydroxychloroquine GI problems such as nausea and vomiting are the most common side effects associated with methotrexate, affecting between 20and 65 percent of RA patients who take the drug. While hair loss is a relatively uncommon side effect in patients who take methotrexate at such doses, up to one third develop mouth ulcers, or sores. Side effects plaquenil/methotrexate. rheumatoid. Switching Medications Without Waiting too Long RA. Methotrexate and its benefit for Sjögren’s patients. Learn when your doctor might switch you to one of these drugs, and how to make the change. like methotrexate, sulfasalazine, hydroxychloroquine, or leflunomide. Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Plaquenil inhibits disease progression. That means, it keeps it from getting worse and progressing faster. We generally will not be able to tell it is doing anything unless we go off it and see how bad things can get -- which of course is not a recommend act! And, Plaquenil takes 2-3 months to build up in your system.