Artemisinin and chloroquine structure

Discussion in 'Canadian Drugs' started by Palamorchuk, 04-Mar-2020.

  1. Hermann New Member

    Artemisinin and chloroquine structure

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Artemisinin itself, the active molecule, was isolated in 1972. When its structure was determined in 1975, it was found that its activity stemmed from a novel endoperoxide bridge. For some years artemisinin was not known in the West, until it was revealed at a conference in 1981. Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium falciparum. Amodiaquine is a 4-aminoquinolone anti-malarial drug similar in structure and mechanism of action to chloroquine. Amodiaquine has tended to be administered in areas of chloroquine resistance while some patients prefer its tendency to cause less itching than chloroquine.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Artemisinin and chloroquine structure

    Anti-Inflammatory and Immunoregulatory Functions of., Arteannuin C15H22O5 - PubChem

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  4. Artemisinin is one of the few antimalarials for which there is no widespread resistance. In the 1970s the chemical structure of a sesquiterpene peroxide with. Chloroquine was discovered by.

    • Artemisinin resistance current status and scenarios for containment..
    • Antimalarial medication - Wikipedia.
    • Artemisinin C15H22O5 - PubChem.

    Therefore, artemisinin-based combination therapy ACT is recommended for the treatment of P. falciparum malaria. Fast acting artemisinin-based compounds are combined with a drug from a different class. Compound formulations have been developed for artemether, artesunate and dihydroartemisinin, as described below. Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. Interactions of artemisinin with amodiaquine, pyronaridine, and chloroquine were therefore investigated against three strains of P. falciparum using a 48-h in vitro culture assay. Two of the strains were chloroquine sensitive and one was partially chloroquine resistant.

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