Malarial chloroquine resistance

Discussion in 'Canadian Pharcharmy Online' started by AngeLsNeba, 27-Feb-2020.

  1. Discipline User

    Malarial chloroquine resistance


    Plasmodium species are transmitted by the bite of an infective female mosquito. Occasionally, transmission occurs by blood transfusion, organ transplantation, needle sharing, nosocomially, or from mother to fetus.

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    The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct. Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

    Travelers going to malaria-endemic countries are at risk for contracting the disease, and almost all of the approximately 1,700 cases per year of malaria in the United States are imported. Malaria is a major international public health problem; 91 countries reported an estimated 216 million infections and 445,000 deaths in 2016, according to the World Health Organization (WHO) World Malaria Report 2017.

    Malarial chloroquine resistance

    The Origins of Antimalarial-Drug Resistance NEJM, Chloroquine Resistance in Plasmodium falciparum Malaria.

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  7. Current status of drug-resistant malaria 10 3. Causes of resistance 12 3.1 Definition of antimalarial drug resistance 12 3.2 Malaria treatment failure 12 3.3 Mechanisms of antimalarial resistance 12 3.3.1 Chloroquine resistance 12 3.3.2 Antifolate combination drugs 13 3.3.3 Atovaquone 13 3.4 Factors contributing to the spread of resistance 13

    • Drug resistance in malaria - World Health Organization.
    • Drug Resistance in the Malaria-Endemic World.
    • Chloroquine Resistance in Plasmodium falciparum - microbewiki.

    Searches for new drugs against chloroquine-resistant malaria, especially as they relate to analogues of chloroquine and chemosensitizing agents against the different forms of P. falciparum and P. vivax, should benefit greatly from research work in this area Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale. Uses. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then.

     
  8. Marusja User

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Cymbalta and Plaquenil drug interactions - eHealthMe Plaquenil Oral Interactions with Other Medication Plaquenil Uses, Dosage & Side Effects -
     
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    Your access to this site was blocked by Wordfence, a security provider, who protects sites from malicious activity. Great Debate examines questions about. Plaquenil Dosage Guide - New Guidelines for Hydroxychloroquine Visual Screening
     
  10. Malaria Chemoprophylaxis Strategies for Risk Groups. Mefloquine is an option for pregnant women who cannot defer travel and who need chemoprophylaxis for areas where chloroquine-resistant malaria is endemic. Some authorities now allow the use of mefloquine in all trimesters, and others advise against using the drug in the first trimester apart from exceptional circumstances.

    Chloroquine - Wikipedia