Tamoxifen versus aromatase inhibitors

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  1. seamobile User

    Tamoxifen versus aromatase inhibitors


    The optimal ways of using aromatase inhibitors or tamoxifen as endocrine treatment for early breast cancer remains uncertain. It is known that both tamoxifen (a selective oestrogen receptor modulator) and aromatase inhibitors are very useful in the management of oestrogen receptor positive early breast cancer in postmenopausal women. This meta-analysis of data from over 30,000 such patients seeks to elucidate optimal treatment. The findings of the meta-analysis were that in the comparison of 5 years of aromatase inhibitor versus 5 years of tamoxifen, recurrence RRs favoured aromatase inhibitors significantly during years 0–1 (RR 0.64) and 2–4 (RR 0.80), and non-significantly thereafter. 10-year breast cancer mortality was lower with aromatase inhibitors than tamoxifen. Warfarin is recommended for the prevention of thromboembolism in atrial fibrillation patients. This report concerns a study involving patients with atrial fibrillation discharged from hospital after an ischaemic stroke. For women who have estrogen receptor-positive breast cancers, hormonal therapy is usually recommended after primary treatment with surgery and possibly chemotherapy and/or radiation therapy. Choices include tamoxifen or aromatase inhibitors such as Arimidex, Femora, or Aromasin. How does the cost and effectiveness of these medications compare, and what do you need to know? What happens if you have difficulty paying for these drugs? We know that even after primary treatment for breast cancer there is a risk of recurrence. And late recurrences several years or even decades after treatment are more common with estrogen receptor-positive tumors. Hormone therapies have been shown to reduce the risk of recurrence and improve survival rates.

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    Oct 6, 2016. What is the Difference Between Aromatase Inhibitors and Tamoxifen. explains the difference between tamoxifen and aromatase inhibitors, and when each are. Professor Mitch Dowsett - Tamoxifen vs Aromatase Inhibitors. The aromatase inhibitors AIs anastrozole, letrozole and exemestane inhibit the conversion of peripheral androgens to estrogen in postmenopausal women, and by reducing plasma estrogen levels to near-undetectable levels, act through a different mechanism to tamoxifen, a selective estrogen-receptor ER modulator. Five years of aromatase inhibitors reduced the recurrence risk vs 5 years of tamoxifen during the first 4 years and reduced the 10-year breast.

    In der adjuvanten Situation werden Aromatasehemmer bei post- menopausaler Patientin bevorzugt in der Sequenz mit Tamoxifen eingesetzt. Welcher der beiden Wirkstoffe zuerst zum Einsatz kommt, wird individuell festgelegt. Auch in der Prmenopause knnen Aromatasehemmer in Kombination mit ovarieller Suppression eingesetzt werden. Jhrlich erkranken rund 70 000 Frauen in Deutschland neu an einem Mammakarzinom (1). In 8085 Prozent der Flle handelt es sich um eine hormonrezeptorpositive Erkrankung, die in der Regel endokrin behandelt wird unabhngig von weiteren systemtherapeutischen Anstzen. Als Therapieoptionen stehen mehrere Substanzklassen zur Verfgung: Im nachfolgenden Beitrag werden die klinische Relevanz der Aromatasehemmer sowie die aktuellen Leitlinien zur endokrinen Therapie erlutert. Wirkmechanismus Die Aromataseinhibitoren unterbinden den letzten Schritt der Umwandlung (Aromatisierung) der androgenen Vorstufen in strogene im Muskel- und Fettgewebe. Aromatase inhibitors stop the production of estrogen in postmenopausal women. Aromatase inhibitors work by blocking the enzyme aromatase, which turns the hormone androgen into small amounts of estrogen in the body. This means that less estrogen is available to stimulate the growth of hormone-receptor-positive breast cancer cells. There are three aromatase inhibitors: Each is a pill, usually taken once a day. Aromatase inhibitors can't stop the ovaries from making estrogen, so aromatase inhibitors are mainly used to treat postmenopausal women. But because aromatase inhibitors are so much more effective than tamoxifen in postmenopausal women, researchers wondered if there were a way to successfully treat premenopausal women diagnosed with hormone-receptor-positive, early-stage breast cancer with an aromatase inhibitor. Results from the SOFT (Suppression of Ovarian Function Trial) study published in 2015 suggest that premenopausal women diagnosed with hormone-receptor-positive breast cancer can be successfully treated with the aromatase inhibitor Aromasin if their ovarian function is suppressed. If you’re a premenopausal woman willing to take medicine to suppress your ovaries, you may be able to take Aromasin instead of tamoxifen for your hormonal therapy treatment.

    Tamoxifen versus aromatase inhibitors

    Aromatase inhibitors versus tamoxifen in early breast cancer - New., Early Recurrence Risk Aromatase Inhibitors Versus Tamoxifen

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  7. Clin Cancer Res. 2005 Jan 15;112 Pt 2925s-30s. Tamoxifen versus aromatase inhibitors for breast cancer prevention. Yue W1, Wang JP, Li Y, Bocchinfuso.

    • Tamoxifen versus aromatase inhibitors for breast cancer prevention..
    • Improved Outcomes With Aromatase Inhibitors vs Tamoxifen in Early..
    • Upfront Adjuvant Aromatase Inhibitor Therapy vs Aromatase Inhibitors..

    Intention-to-treat log-rank analyses, stratified by age, nodal status, and trial, yielded aromatase inhibitor versus tamoxifen first-event rate ratios. A fact sheet that describes types of hormone therapy, its role in preventing and treating breast cancer, and possible side effects. This F1000 commentary rates a meta-analysis on aromatase inhibitors and when. versus tamoxifen as primary adjuvant endocrine therapy in postmenopausal.

     
  8. MTay Well-Known Member

    Beta blockers are widely used in the management of cardiac conditions and thyrotoxicosis, and to reduce perioperative complications. Asthma and chronic obstructive pulmonary disease (COPD) have been classic contraindications to the use of beta blockers because of their potential for causing bronchospasm. The identification of cardioselective beta blockers that have significantly greater affinity for beta receptors offers a sub- group of beta blockers that are less likely to cause bronchospasm. Salpeter and associates analyzed data from randomized, blinded, placebo-controlled trials to evaluate the effect of cardioselective beta blockers on patients with reactive airway disease, including asthma or COPD with a reversible component. Eligible studies could use oral or intravenous dosing given as a single dose or as continuous treatment. Of the 29 studies included in this meta-analysis, 19 studied single-dose treatment in a total of 240 patients. The cardioselective beta blockers without intrinsic sympathomimetic activity that were used in the study included atenolol, metoprolol, bisoprolol, and practolol. Beta blockers safe for most patients with asthma or COPD? - PulmCCM Cardioselective β-Blockers Generally Are Safe in Asthma Patients Prescribing of b-adrenoceptor antagonists in asthma - Thorax
     
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