Please review the following URL and make sure that it is spelled correctly. Up to 60 percent of adults report that they have had nocturnal leg cramps. Chloroquine to treat gbm Plaquenil breastfeeding Plaquenil macular oct Myositis refers to any condition causing inflammation in muscles. Weakness, swelling, and pain are the most common myositis symptoms. Myositis causes include infection, injury, autoimmune conditions, and drug side effects. Treatment of myositis varies according to the cause. I have been on plaquenil for around 8 months or so but these leg cramps have just gotten worse and the ladies I work with told me to get calcium with magnesium. That would help out with the leg cramps but I am worried with all the meds that I take I am afraid that it might interact with the meds. I see the doc in a few weeks and ask what he thinks. Re Do you have muscle pains/spasms with lupus or hughes? I often get severe spasms in my back and with a flare, my muscles hurt in my arms and legs. I am not sure if it is from lupus or fibromyalgia as I suffer from both diseases. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. Plaquenil and muscle spasms Nighttime Leg Cramps Meds That Hurt, Meds That Help - GoodRx, Foot and leg cramps Arthritis Information Plaquenil toxicity guidelineAre you more likely to get sick while taking plaquenilCan plaquenil make psoriatic arthritis worseWill plaquenil stop hair lossPlaquenil generic cost Sep 13, 2019 Frequency not reported Skeletal muscle myopathy or neuromyopathy leading to progressive weakness and atrophy of proximal muscle groups, depression of tendon reflexes and abnormal nerve conduction studies. Myopathy may be reversible after therapy discontinuation, but recovery may take many months. Nervous system Plaquenil Side Effects Common, Severe, Long Term -. Do you have muscle pains/spasms with lupus or hughes?. How Lupus Affects the Muscles, Tendons and Joints Lupus.. Among her worst symptoms of this horrible flare are very severe muscle spasms and intense neuropathy. When she tries to relax in the evening and into the night, these muscle spasms kick in. They are so severe that we've made multiple trips to the ER for IV meds. I use a bar of ivory free soap in our sheets also just like Ezra suggested. I found out about this very strange trick when I was in the hosp all the time and had those cramps/spasms and a nurse told me about it. I thought she was nuts but would try anything lol. It worked! This has also been a huge help for hubby and his RLS! A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects.