Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil skin sloughing How long does it take plaquenil to damage bones Plaquenil dosage for sjogrens Efficacy of plaquenil treatment for rheumatoid arthritis Mar 12, 2019 Retinal detachment Retinal detachment describes an emergency situation in which a thin layer of tissue the retina at the back of the eye pulls away from the layer of blood vessels that provides it with oxygen and nutrients. Retinal detachment is often accompanied by flashes and floaters in your vision. Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Retinal Detachment in a Patient with Hydroxychloroquine Toxicity Article PDF Available in Journal of Ophthalmic & Vision Research 142226 April 2019 with 27 Reads How we measure 'reads' While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil retinal detachment Hydroxychloroquine-Induced Retinal Toxicity - American., Hydroxychloroquine Plaquenil Toxicity and. Humira and plaquenilIcd 10 plaquenil Jun 11, 2009 Retinal toxicity has been shown in patients taking greater than 3 mg/kg/day of chloroquine or 6.5 mg/kg/day of hydroxychloroquine. While most cases of toxicity have been reported for chloroquine, hydroxychloroquine has supplanted it as the more commonly used treatment agent for both RA and SLE. 2 Common Medications That May Be Toxic to the Retina. PDF Retinal Detachment in a Patient with Hydroxychloroquine Toxicity. Plaquenil Related Eye Problems - Fraser Eye. Plaquenil hydroxychloroquine sulfate, Sanofi-Aventis and the less-used chloroquine are antimalarial drugs with anti-inflammatory properties that are used for the management of a spectrum of inflammatory conditions. Initially retinal toxicity due to long-term use of chloroquine Aralen for malaria was reported in 1959 by Hobbs et al. 106 Currently, hydroxychloroquine sulphate Plaquenil is the quinoline agent of choice for the treatment of autoimmune diseases with a far lower incidence of adverse reactions. 107, 108 Hydroxychloroquine has been associated with many ocular toxic effects including keratopathy, ciliary body dysfunction, lens opacities, outer retinal damage, and pigmentary retinopathy. In particular, chloroquine and hydroxychloroquine Plaquenil are two such medications, with the potential for retinal toxicity. Given that the retinal damage from these medications is largely irreversible, screening by a retinal specialist is critical to detect early retinal toxicity to try and limit the extent of visual loss.