It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. I've been off it a few days and thankfully my plumbing is back to normal it seems and the huge acne has stopped/gone. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and... Since I'm a woman I managed to bypass the plumbing problems while on the prednisone (I'm on 30 mg), but you're right, the acne is BAD!! Considering the state my joints are in though, I suppose that's the least of my problems. Chloroquine hemozoin Plaquenil and discoid lupus dosage Plaquenil maculopathy visual field Plaquenil and other medications Hydroxychloroquine does take a while to take effect. Arthritis UK gives a figure of around 12 weeks, whilst the American College of Rheumatology says, "symptoms can start to improve after 1-2 months, but it may take up to 6 months before the full benefits are felt". My own rheumy said, "3-4 months". Feb 09, 2012 Plaquenil is actually a treatment for malaria but when given to patients with Lupus the patients improved. Over the long term the medication protects your blood vessels which reduces long term complications. I have had Lupus for 23 years. Eventually the side effects abate. It should also help with joint and muscle pain. How long does it take for plaquenil to work? I just started about 6 weeks ago, the rheum said it can take up to a year. I just started about 6 weeks ago, the rheum said it can take up to a year. Let me know how you are doing on it! My doctor was only able to find it after I requested a MRI of my hands. Of course neither has the prednisone, sulfasalazine, or methotrexate. Hi guys, I was diagnosed with RA in April 08 and I'm 29 years old. I've been on plaquenil for over 4 months and it hasn't done squat for me. How long does it take plaquenil to work for lupus How is plaquenil hydroxychloroquine used to treat lupus?, Systemic Lupus Erythematosus - Does anyone else take. Teva chloroquinePlaquenil and eye photosensitivityHydroxychloroquine sulfate highInjection dose of chloroquine How long did it take for Plaquenil to work? I'm just curious how long it took everyone to start to notice a different. My dr said it would take 6-12 weeks to start to notice anything but I only started Plaquenil 3 weeks ago and I swear I can already notice a difference. How long did it take for Plaquenil to work? lupus. Plaquenil - does it take long time to work? - Lupus - Inspire. Protecting your eyesight when taking Plaquenil Lupus.. It does not work against certain. It may take several weeks or months to see improvement if you are taking this for lupus or arthritis. Hydroxychloroquine may not prevent malaria in all cases. Aug 10, 2012 Typically plaquenil takes 4 to 6 months to take full effect in controlling systemic lupus. It makes you a little less photosensitive as well. Please make sure you have a baseline field of vision test. It is just precautionary, but you do need a baseline. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness. How does Plaquenil work? Plaquenil changes the way your immune system works. In some kinds of lupus, your immune system attacks your body instead of protecting it.