Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Plaquenil et psoriasis Plaquenil induced rash Lariam vs plaquenil Plaquenil generico Second opinion said start on methotrexate, wait on Enbrel. Started 15 mg oral methotrexate in April 2019, with 5 mg daily prednisone. At 3 month appointment in August 2019, doctor wants to slowly taper off prednisone, reducing to 4 mg for a month to prevent a flare, while adding 200 mg hydroxychloroquine twice a day. Learn when your doctor might switch you to one of these drugs, and how to make the change. like methotrexate, sulfasalazine, hydroxychloroquine, or leflunomide. I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. How to switch from plaquenil to methotrexate Plaquenil vs. Methotrexate side effect and effectiveness., How You Can Work With Your Doctor to Switch Your RA Meds Plaquenil alternatives lupus I went to see a new rheum and he took me off the Plaquenil to see what symptoms would show. I have not been formally diagnosed yet. It took 6 weeks to see the results. I went into a bad flare. Went back to rheum and he decided to put me on Methotrexate. I have only taken it once, so I am not sure what the results will be. Stopping Plaquenil - General Discussion - Life With Lupus. Which would you pick and why? - Plaquenil or Methotrexate. Compare Plaquenil vs Methotrexate -. Methotrexate is a liquid injection medication I use for my RA. This was prescribed to my by my rhumotologist on 10/10/09. I originally started seeing her for my Lupus. I was also prescribed plaquenil, and folate acid. Of course the doseage of all the meds was low. Methotrexate or Plaquenil. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. I never had any side-effects of dire consequence, but many on this forum have. Methotrexate may take longer to become effective, but USUALLY, it will take effective within the time frame you're looking at. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in.