Hydroxychloroquine renal toxicity

Discussion in 'Chloroquine 150 Mg' started by EnterDM, 21-Feb-2020.

  1. legato.di Guest

    Hydroxychloroquine renal toxicity

    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. The risk of retinal toxicity increases with the duration of use cumulative dose, age, preexisting retinal and macular disease, and renal or liver disease. We report a case of severe retinal toxicity precipitated by renal impairment and review the literature on the use of hydroxychloroquine in renal impairment. He pointed out that these findings have been validated in several studies using other patient populations. He concluded that the risk is very real of developing retinal toxicity with prolonged use of hydroxychloroquine. The dose, duration, presence of renal disease and use of other drugs such as tamoxifen all contribute to the increased risk.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Hydroxychloroquine renal toxicity

    Risk of Retinal Toxicity in Longterm Users of Hydroxychloroquine, A Case of Severe Hydroxychloroquine-Induced Retinal Toxicity.

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  6. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydroxychloroquine in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving this medicine. Breastfeeding

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    Recent findings The risk of antimalarial-induced retinal toxicity is better predicted by calculating the daily dosage based on 5 mg/kg total body weight rather than 6.5 mg/kg lean body weight and reducing dosage in patients with risk factors such as renal failure. The risk of retinal toxicity after 5 years is substantially increased even when. A case of severe hydroxychloroquine-induced retinal toxicity in a patient with recent onset of renal impairment a review of the literature on the use of hydroxychloroquine in renal impairment Case Rep Ophthalmol Med Macular toxicity is related to the total cumulative dose rather than the daily dose. Regular eye screening, even in the absence of visual symptoms, is recommended to begin when either of these risk factors occurs. Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula.

  7. Andytolsty1 New Member

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  8. MashkO Guest

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  9. Xenia Moderator

    The effect of hydroxychloroquine on glucose control and. In this context, those patients with fasting blood sugar level 100–125 mg/dL or hemoglobin A1c 5.7–6.5% were included in the study. All patients were physically examined by the physician and anthropometric parameters such as weight, height, body mass index and waist circumference were measured.

    Lupus SLE Blood sugar levels" Lupus Community - Support.
  10. inWebs New Member

    Hydroxychloroquine Reviews Everyday Health Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects.

    Do either hydroxychol/Plaquenil put you at risk for.