Role of hydroxychloroquine in type 2 diabetes mellitus ppt

Discussion in 'Chloroquine Drug' started by LSa, 01-Mar-2020.

  1. gandon XenForo Moderator

    Role of hydroxychloroquine in type 2 diabetes mellitus ppt


    It has been shown in multiple SLE populations to associate with improved survival (1-3) and specifically has been found to be effective in the treatment of cutaneous disease(4), arthritis(5), with an augmenting effect on the efficacy of mycophenolate mofetil in the management of nephritis(6) amongst other positive health effects(7, 8). Füzéry AK, Breaud AR, Emezienna N, Schools S, Clarke WA. Hydroxychloroquine is a safe, non-immunosuppressive therapy with good tolerability. A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spectrometry.

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    Inflammation is considered to play a crucial intermediary role in pathogenesis of diabetes and number of co-existing disease. Hydroxychloroquine, a long-standing safe and inexpensive treatment for autoimmune disorders, may theoretically improve glucose tolerance and prevent diabetes. Hydroxychloroquine, inhibits insulin Abnormalities including insulin resistance, dyslipidemia, type 2 diabetes mellitus, hypertension and cardiovascular problems. 26 It has been suggested that visceral adiposity appears to play a strong role in the pathogenesis of sleep apnea and manifestations that frequently accompany the disorder namely hypertension and its sequlae.27 Alternatively, diabetes can be diagnosed by two separate fasting glucoses ≥ 126 mg/dL; with symptoms, a glucose ≥ 200 mg/dL confirmed on a separate day by a fasting glucose ≥ 126 mg/dL; or 2 -hour postload glucose ≥ 200 mg/dl during an oral glucose tolerance test.

    There is also significant controversy surrounding how to best dose this medication, with some advocating dosing based on actual body weight (capped at 400 mg per day), whilst others are in favor of calculating the daily dose based on ideal body weight. Adherence to treatment in systemic lupus erythematosus patients. However, there are increasing concerns about retinopathy, in particular, in light of new screening methods, which are thought to have increased sensitivity(9). Costedoat-Chalumeau N, Pouchot J, Guettrot-Imbert G, Le Guern V, Leroux G, Marra D, et al.

    Role of hydroxychloroquine in type 2 diabetes mellitus ppt

    Hydroxychloroquine a diabetic drug in disguise? BMJ Case., Sleep and Type 2 Diabetes Mellitus- Clinical Implications

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  4. Type 2 diabetes mellitus T2DM has been related to alterations of oxidative metabolism in insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of mitochondrial.

    • The role of mitochondria in insulin resistance and type 2..
    • Management of Type 2 Diabetes Mellitus - Michigan Medicine.
    • Type 2 Diabetes Mellitus - Pathophysiology.

    Background. Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia. It affects millions of people globally. In spite of many antidiabetic drugs that are available, an adequate level of control remains challenging. Hydroxychloroquine is an immunomodulatory drug that has been used for the treatment of malaria and autoimmune diseases. The onset of diabetes occurs only after a significant decline in beta-cell function. Because the progression of diabetes is inevitable, most patients with type 2 diabetes will require combination therapy to reach an acceptable level of glycemic control. DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Hydroxychloroquine HCQ, a commonly used antimalarial drug in rheumatic diseases, has shown favorable metabolic effects on both glucose control and lipid profiles. We describe a case of a young woman with type 1 diabetes whose glycemic control was optimized.

     
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    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. SAFETY DATA SHEET - Fisher Scientific Chloroquine - FDA prescribing information, side effects and uses Dimethyl Sulfoxide DMSO Solubility Data
     
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