But there's evidence the drug can activate a virus that can increase the risk of lymphoma and similar cancers in some patients. A number of reports have linked methotrexate with lymphoma and similar cancers of the lymph glands, says senior researcher Shannon C. Kenney, MD, a microbiologist and infectious disease specialist with the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill. Can plaquenil cause achy joints and muscles Plaquenil teeth What Conditions Does This Treat? Originally, hydroxychloroquine was used to prevent and treat malaria and was considered very effective. Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This risk may increase if. If you aren’t responding to methotrexate after a two-month period, your rheumatologist may try some kind of combination therapy, such as adding sulfasalazine and hydroxychloroquine called triple therapy or adding a biologic drug such as etanercept Enbrel, adalimumab Humira, or infliximab Remicade. Some studies have indicated that the drug's immune-weakening effect places people at risk for viral-associated lymphomas. Also, studies have shown that when rheumatoid arthritis patients quit taking methotrexate, their lymphoma went into regression, another sign that the drug directly contributes to the cancer, she tells Web MD. Hydroxychloroquine increse methotrexate Methotrexate vs Plaquenil Comparison -, Hydroxychloroquine Oral Uses, Side Effects, Interactions. Drug hydroxychloroquine oral-tablet 200mgChloroquine & Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Common Questions About Taking Methotrexate for Rheumatoid.. Which would you pick and why? - Plaquenil or Methotrexate. Lower the convulsion threshold e.g. mefloquine may increase the risk of convulsions. Antiepileptics The activity of antiepileptic drugs might be impaired if co-administered with PLAQUENIL. Methotrexate Combined use of methotrexate with PLAQUENIL has not been studied and may increase the incidence of adverse effects. PLAQUENIL. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.