Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine synthesis mechanism Plaquenil mosquito How plaquenil works Plaquenil has replaced chloroquine because it produces less retinal side effects. Aside from its initial intended use, it has been also used for the management of rheumatoid arthritis, systemic lupus erythematosus and several other connective tissue disorders 1. Jan 04, 2015 I started taking it 8 months ago and recently experienced gastrointestinal symptoms including some favorite foods suddenly tasting awful. Doc thinks it may be Plaquenil? What are your experiences? I also have fatigue and exercise intolerance and don't know if this is from UCTD or side effects of breast cancer radiation 3 yrs ago. Plaquenil may interact with Cymbalta and may reduce the effectiveness of methotrexate. Magnesium should also be taken 4 hours apart because it also affects the way the body absorbs the Plaquenil. It can also affect the body's vitamin d levels. Taking B6 with Plaquenil can get rid of skin nodules associated with RA. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How to reverse the side gastrointestinal side effects of plaquenil Let me tell you what weaning down from Plaquenil is like., Side effects from plaquenil - Autoimmune diseases - Inspire Chloroquine and early pregnancyCan hydroxychloroquine cause mental problemsHydroxychloroquine cause rash I started taking Plaquenil, and I'm supposed to be taking two 200mg pills a day, but I'm only taking one for a week to ease into it. So far I've woken up every morning very nauseous and with a lot of stomach pain and fatigue early in the day plus diarhea. I heard the side effects go away after a. Plaquenil Side Effects Go Away? DailyStrength. Starting Plaquenil DailyStrength. Will you have Hair loss with Plaquenil - eHealthMe. The most common side effects are GI, although patients can also have headaches, tinnitus, itching, and rashes 2. In addition, it is important to note that HCQ can cause retinopathy with prolonged use. Aug 30, 2011 No treatment to reverse chloroquine or hydroxychloroquine toxicity. Recommend cessation of the medication, but visual function rarely recovers, especially in the later stages of the disease. Continued deterioration in visual function can occur for a year after discontinuing hydroxychloroquine, possibly due to slow clearance of the medication from the retina and body. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage.