It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Moa of plaquenil Chloroquine and osmotic lysis Ophthalmologic complication of hydroxychloroquine Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis. In severe cases, rheumatoid arthritis can cause pain throughout your entire body, including Muscle aches. Fatigue. Malaise. Poor appetite. Depression. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil arthritis pain Plaquenil and pain" Rheumatoid Arthritis Community., What Is Hydroxychloroquine and How Does It Help Arthritis. Plaquenil dark spots Hi, I have been on Plaquenil an Arava for about 2 and a half years now. I was also on Orencia for 2 years. I just started back with Arthrotec. Te Orencia stopped working for me and I just started Simponi last week. I was having increased stiffness and pain in the achilles tendon area and it was real tough walking. PLAQUENIL" Rheumatoid Arthritis Community - Support Group. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. However, glucosamine and the placebo both relieved arthritis pain better than taking nothing, particularly in people who have moderate to severe pain from knee osteoarthritis. Chondroitin. Chondroitin may provide modest pain relief from osteoarthritis, although study results are mixed. Also, generic plaquenil hydroxychloroquine is often associated with more GI side effets than the name brand. Arthritis Center Founded in 1998, the Arthritis Center at Johns Hopkins is dedicated to providing quality education to patients and healthcare providers alike. Hydroxychloroquine may be used with other arthritis medicines including other DMARDs such as methotrexate. steroid medicines such as prednisolone or cortisone injections into the joint. anti-inflammatory medicines NSAIDs such as naproxen Naprosyn and ibuprofen Brufen, Nurofen. simple pain.