Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil oral mucosa Can plaquenil cause hearing loss Effects of long term use of plaquenil Chloroquine-resistant strains of Plasmodium falciparum, for example, which originally appeared in South-East Asia and South America are now found in East Asia and sub-Saharan Africa 1. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. ovale, and P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Approved indication For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations Chloroquine-sensitive uncomplicated malaria Plasmodium species or species not identified 600 mg base 1 g salt orally at once, followed by 300 mg base 500 mg salt orally at 6, 24, and 48 hours. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Plasmodium falciparum samuel martin chloroquine On the Mechanism of Chloroquine Resistance in Plasmodium., Chloroquine - Wikipedia Plaquenil cause low wbc The emergence of Plasmodium falciparum resistance to anti-malarial drugs has thwarted malaria control efforts and remains a major obstacle to malaria elimination throughout the world. Chloroquine was one of the first drugs to be used on a wide scale for the treatment of malaria. Chloroquine resistance emerged independently in different geographic regions. The return of chloroquine-susceptible Plasmodium.. Chloroquine Dosage Guide with Precautions -. Enantiopure substituted pyridines as promising.. Volume 23, Issue 7 Pages 293-340 July 2007. K. Samuel Martin, Yoshihiro Urade. Two competing models explaining chloroquine resistance in Plasmodium. Abstract We investigated chloroquine sensitivity to Plasmodium falciparum in travelers returning to France and Canada from Haiti during a 23-year period. Two of 19 isolates obtained after the 2010 earthquake showed mixed pfcrt 76K+T genotype and high 50% inhibitory concentration. Fluoxetine hydrochloride enhances in vitro susceptibility to chloroquine in resistant Plasmodium falciparum Article PDF Available in Antimicrobial Agents and Chemotherapy 36122761-5.