Retinal changes with plaquenil

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  1. tatam New Member

    Retinal changes with plaquenil


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. In a separate study designed to compare chronically treated patients with and without ophthalmoscopic evidence of toxicity, significant thinning of the inner, outer and full thickness retina was observed in patients with clinically apparent retinal toxicity, whereas only selective thinning of the inner retina was detected in the group without fundus changes. 13 Once again, RNFL thinning was absent in patients with chronic HCQ exposure and no fundus changes; however, the group with fundus. Discontinued and the patient closely observed for possible progression of the abnormality. Retinal changes and visual disturbances may progress even after cessation of the therapy. See ADVERSE REACTIONS section Suicidal behavior has been reported in very rare cases in patients treated with hydroxychloroquine.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Retinal changes with plaquenil

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  4. Hydroxychloroquine Plaquenil, Sanofi-Aventis remains widely used in the treatment of various rheumatologic disorders. A small percentage of patients exposed to hydroxychloroquine will develop irreversible, and potentially progressive, retinal toxicity for which no effective treatment exists.

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    The changes are most often permanent, but in some cases, vision has improved. Most rheumatologists recommend patients undergo a baseline eye examination prior to starting Plaquenil and be re-examined in the future depending on their risk for developing the condition. Risk factors include advanced age and having pre-existing retinal disease. PLAQUENIL is indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults. Rheumatoid Arthritis. PLAQUENIL is indicated for the treatment of acute and chronic rheumatoid arthritis in adults. CONTRAINDICATIONS. Use of PLAQUENIL is contraindicated in patients with known hypersensitivity to 4­ Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have

     
  5. Ultima Thule Well-Known Member

    In some cases, they may not be available in every strength or form as the brand-name drug. HCQS 200 MG Tablet Uses, Side Effects, Composition & Dosages Plaquenil Hydroxychloroquine Sulfate PLAQUENIL®
     
  6. leks8881 Moderator

    Download PDF Many systemic medications may cause retinal toxicity. Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil Oral Uses, Side Effects, Interactions. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  7. The Risk of Retinal Toxicity with Plaquenil Aug 29, 2014 As a precaution, patients treated with Plaquenil are advised to get a baseline eye exam prior to starting the drug and then annually thereafter This information provided by Neil I. Stahl, MD & Tongalp H. Tezel, MD was first printed in the The Moisture Seeker, SSF's patient newsletter for members.

    Plaquenil Side Effects on Your Eyes and Vision
     
  8. linuxoid Guest

    DMARDs for Treating Rheumatoid Arthritis In rare cases, Plaquenil can adversely affect the eyes, and patients taking this medicine should be seen by an ophthalmologist at least once a year. Long-term use of azathioprine is associated.

    Plaquenil -