Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil 400 mg Chloroquine lc3-ii Plaquenil causing hearing loss Chloroquine A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Doctors treat malaria by using anti-malarial drugs, such as chloroquine or quinine.’ ‘Quinine formed the basis for synthesising the commonly used antimalarial drugs, chloroquine and mefloquine.’ ‘The situation is becoming more difficult because the most widely used antimalarial drug chloroquine is losing its effectiveness.’ Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Chloroquine define Chloroquine definition of chloroquine by Medical dictionary, CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and. Hydroxychloroquine immune suppressantHydroxychloroquine adderall interactionCan plaquenil cause skin pigment to darkenPlaquenil and visual field testing Chloroquine definition a synthetic drug, CHClN, used in treating malaria, certain kinds of arthritis, etc. Origin of chloroquinefrom chloro- + quinoline. Chloroquine dictionary definition chloroquine defined. Chloroquine Definition of Chloroquine by Lexico. Define chloroquine Dictionary and Thesaurus. Chloroquine enters the red blood cell, inhabiting parasite cell, and digestive vacuole by simple diffusion. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Chloroquine, synthetic drug used in the treatment of malaria. Chloroquine, introduced into medicine in the 1940s, is a member of an important series of chemically related antimalarial agents, the quinoline derivatives. Chloroquine is administered orally as chloroquine phosphate. It also can be Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion.