Please review the following URL and make sure that it is spelled correctly. Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Vivax malaria treatment chloroquine Plaquenil red spots on chest Plaquenil 20 mg Fatigue is one of the most common symptoms of fact, most people with lupus have fatigue at some point in their illness. “When lupus hit, it was like running into a wall at 80 mph. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. I have been prescribed Plaquenil 400 mg daily to see if there is any improvement in my fatigue etc. I have been told the most common side effects of Plaquenil are increased sun sensitivity, nausea and sometimes eye problems. But after doing a bit of reading, it seems hair loss can sometimes be an issue with this medication as well. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil for fatigue Is lethargy and tiredness a side effect of hydroxychloroquine?, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Can plaquenil cause cancerMthfr and plaquenilRaking tylenol after using plaquenilSudden withdrawal of hydroxychloroquine Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Is extreme fatigue a side effect of Plaquenil?. UCTD and Plaquenil DailyStrength. Is extreme fatigue a side effect of Plaquenil - NRAS. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Description and Brand Names. Drug information provided by IBM Micromedex US Brand Name. Plaquenil; Descriptions. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. I have been on Plaquenil for years. It has not helped me with fatigue. Things like vitamins and exercise might assist with decreasing the fatigue level. I have been on 2 Dmards and a biologic for the longest time. I also take Tramadol for pain and now Indomethicin has been added to the mix to help with stiffness.