About 120 million people around the world with Type 2 diabetes - and two million in Canada - take the drug metformin to control their disease. While doctors know metformin needs to interact with insulin to be effective, and that it can't lower blood sugar on its own, no one has been able to explain how and why this happens. Researchers at Mc Master University are the first to unlock that mystery with their discovery metformin works on fat in the liver. Their research is published in today's issue of the journal Nature Medicine. "The key is that metformin doesn't work to lower blood glucose by directly working on the glucose. It works on reducing harmful fat molecules in the liver, which then allows insulin to work better and lower blood sugar levels," said Greg Steinberg, associate professor in the Department of Medicine of the Michael G. He also holds the Canada Research Chair in Metabolism and Obesity and is a co-director of the Metabolism and Childhood (MAC)-Obesity Research Program. His research team included scientists in Alberta, Australia and Scotland. Hormonal levels are fine, blood fine, ultrasounds and all the other fancy xrays they do, fine. Until one day I was feeling that pain, and I drove to the hospital to have them give me an ultrasound, and there it was. So, if you've got a feeling that something is wrong, and it doesn't go away, don't give up!!!! I also recently found out I have non-alcoholic fatty liver(found this out along-side of PCOS). Finally diagnosed after years and years of "no findings". Apparently I'd been taking tests during the perfect times of everything being stable. Is it ok to take Metformin 500mg(just started) with that? Explain there are options available whatever the situation may be. I was told by the hospital that I had it, and my doctor prescribed it to me... But she never mentioned the liver thing so I'm kinda wondering if she even knew..had Non-alcholoic FL for yearsss. its due to a carb-heavy diet (at least in my case it was, and seems to be more common in latinos due to the corn/bean/rice presence in our cuisine)Fertility or Infertility is a very sensitive and personal matter. Where to purchase generic viagra Propranolol review Duloxetine patient assistance McMaster University researchers discover how metformin drug works on fat in the liver. Steinberg said that most people taking metformin have a fatty liver, which is frequently caused by obesity. Nonalcoholic fatty liver disease NAFLD is the most common liver disorder worldwide. Its prevalence ranges 10–24% in the general population. The liver is one of the most complicated organs in the body and plays a huge role in handling sugars. When should you take metformin to work with the liver? Since July last year, every day I ran 3.5 mile on a running machine. I tried to improve the situation by physical exercise. Sadly, weight was not reduced and a recent ultrasound exam showed fatty liver worsened. Further IGT test showed both glucose level and insulin level are moderately higher than normal. Doctor told me it is the case of insulin resistance associated with fatty liver. I feel quite discouraged that I really tried my best but could not see any improvement. Can anyone share the experience with me how to make things better with diet plus physical exercise? Two widely used medicines in China are Metformin and TZDs. Metformin hurts stomach and I already have serious stomach problems. Or can anyone introduce me some medicine from natural materials, instead of from chemicals? @kinmeta I have no answers for you, but your post brings up something I have wondered about for quite a while. My cirrhosis was diagnosed in 2014 and the hepatologist said I probably had it for about 10 years. 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One of the ways metformin helps to control blood glucose is by inhibiting glucose release from the liver. So metformin does directly affect the liver. Elevated liver enzymes AST/ALT are an indication of the liver repairing itself. He has prescribed Metformin for Fatty Liver NOT for diabetes. Doing a google it seems that there is no meds for fatty liver and Metformin is for diabetes. He has.