Tamoxifen for prevention of breast cancer

Discussion in 'Prescription Drug' started by aibolit24, 24-Aug-2019.

  1. pava New Member

    Tamoxifen for prevention of breast cancer


    If you're at high risk of breast cancer, you may be able to improve your odds of staying cancer-free by taking certain medicines, an approach known as chemoprevention or preventive therapy. Medications for breast cancer chemoprevention are the subject of much ongoing research. Tamoxifen blocks the effects of estrogen — a reproductive hormone that influences the growth and development of many breast tumors. Tamoxifen belongs to a class of drugs known as selective estrogen receptor modulators (SERMs), and it reduces the effects of estrogen in most areas of the body, including the breast. In the uterus, tamoxifen acts like an estrogen and encourages the growth of the lining of the uterus. Tamoxifen is prescribed as a pill you take once a day by mouth. For breast cancer risk reduction, tamoxifen is typically taken for a total of five years. Also known as: Soltamox The following information is NOT intended to endorse drugs or recommend therapy. I stopped taking the Effexor (doctor wasn't too happy) thinking that was causing some adverse effects. That worked for a short period of time so they upped the dosage to 100 mg at night. My Oncologist increased the Effexor dosage from 75 mg to 150 mg per day. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."I've been taking Tamoxifen for 10 months now. The doctor prescribed Effexor at the same time to combat any menopausal symptoms. She assure me the Effexor and Black Cohoosh would STOP the sweating... SWEATING INCREASED AND I AM MORE DEPRESSED THAN EVER. It seems as if I get over one side effect and here comes another. I am trying to stick with it, but it keeps changing.""I have taken Tamoxifen for 5 years. I have been taking Effexor XR longer than I have been on Tamoxifen. I have had fatigue, chills, shortness of breath, night sweats, blurred vision, difficulty sleeping. I can't concentrate and my appetite has decreased. I can't wait till my 5 years is up I stayed on this pill because I want my risk of cancer to be low. The worst side effect is cramping throughout my body.""I have been taking tamoxifen for less than a month. I have to stay on this for 5 years.""I have been on Tamoxifen for 4 1/2 years I have insomnia mood swings and other small side effects. I had a sonogram last month that revealed a very small fibroid and fluid in my uterus.

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    PDF The finding of a decrease in contralateral breast cancer incidence following tamoxifen administration for adjuvant therapy led to the concept that the drug. Read about preventing breast cancer. As the causes of breast cancer aren't fully understood, it's not known if it can be prevented altogether. Four previously published randomised clinical trials have shown that tamoxifen can reduce the risk of breast cancer in healthy women at increased risk of.

    Hormones are substances that function as chemical messengers in the body. They affect the actions of cells and tissues at various locations in the body, often reaching their targets through the bloodstream. The hormones estrogen and progesterone are produced by the ovaries in premenopausal women and by some other tissues, including fat and skin, in both premenopausal and postmenopausal women and men. Estrogen promotes the development and maintenance of female sex characteristics and the growth of long bones. Progesterone plays a role in the menstrual cycle and pregnancy. Estrogen and progesterone also promote the growth of some breast cancers, which are called hormone-sensitive (or hormone-dependent) breast cancers. Hormone-sensitive breast cancer cells contain proteins called hormone receptors that become activated when hormones bind to them. The drug tamoxifen can help prevent breast cancer in women at an increased risk of the disease. But many women who stand to benefit from tamoxifen do not take the drug—a pill—because of concerns about side effects, such as hot flashes and . To explore alternatives to oral tamoxifen that might have fewer side effects, researchers are testing a topical form of the drug in two clinical trials. These randomized placebo-controlled studies are evaluating a gel formulation of tamoxifen called 4-hydroxytamoxifen (4-OHT) that women apply directly to the breasts. The goal of this research is to find out if delivering a form of tamoxifen topically results in the same level of the drug in the breast but leads to lower levels of the drug in the blood and other parts of the body compared with oral delivery, according to Brandy Heckman-Stoddard, Ph. “With lower levels of the drug in the body, women would potentially have fewer side effects,” she added. D., of Northwestern University Feinberg School of Medicine led a small study that compared the proliferation of abnormal cells in the lining of the breast duct—a condition known as ductal carcinoma in situ (DCIS)—among women treated with the gel applied to the breast skin and women treated with oral tamoxifen. (In women with DCIS, the abnormal cells have not yet spread to other tissues in the breast.) “We found a similar reduction in the growth of DCIS cells from both the gel and the pill form of the drug, and the concentrations [of tamoxifen] in the breasts of women who were treated with the gel were quite good,” said Dr. Khan, who is leading one of the new clinical trials of the tamoxifen gel.

    Tamoxifen for prevention of breast cancer

    Tamoxifen for Breast Cancer Treatment and Prevention - WebMD, Breast cancer in women - Prevention - NHS

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  6. Lancet Oncol. 2015 Jan;16167-75. doi 10.1016/S1470-20451471171-4. Epub 2014 Dec 11. Tamoxifen for prevention of breast cancer extended long- term.

    • Tamoxifen for prevention of breast cancer extended long. - NCBI.
    • Tamoxifen for prevention of breast cancer. - PubMed Central..
    • Tamoxifen for women at high risk of breast cancer - NCBI - NIH.

    Four previously published randomised clinical trials have shown that tamoxifen can reduce the risk of breast cancer in healthy women at. In 1991, my National Surgical Adjuvant Breast and Bowel Project NSABP colleagues and I concluded that enough biological and clinical data were available to. Breast cancer chemoprevention — Drugs for breast cancer prevention in high. increased risk of blood clots or uterine cancer, as tamoxifen and.

     
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    In a September 2013 clinical report, “The Transfer of Drugs and Therapeutics Into Human Breast Milk: An Update on Selected Topics,” the American Academy of Pediatrics (AAP) provides guidance to physicians regarding drug exposure and reaffirms the recommendation that most medications and immunizations are safe during lactation. It is important for breastfeeding mothers to inform their child’s pediatrician about all of the medications they are taking, including herbal products. Not all drugs are present in clinically significant amounts in human milk or pose a risk to the infant. Certain classes of drugs can be problematic, either because of accumulation in breast milk or due to their effects on the nursing infant or mother. The most common products of concern include pain medications, antidepressants, and drugs to treat substance/alcohol abuse or smoking cessation. Breastfeeding does not interfere with the infant’s immune response to most routine immunizations and may even protect against the incidence of fever after being immunized. Vaccines recommended for the mother during the postpartum period are designed to protect the infant and the lactating mother. HELP Can I Take Amoxicillin While Breastfeeding? IS IT SAFE Antibiotics and Breastfeeding – 5 Things You Need To Know. Breastfeeding and Medication -
     
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