Tamoxifen therapy for breast cancer

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  1. wrm Guest

    Tamoxifen therapy for breast cancer


    Tamoxifen, also known by the brand name Nolvadex, is one of the more commonly prescribed medications to prevent breast cancer recurrence, and when used appropriately, may reduce the risk of recurrence (of breast cancer coming back) by roughly 50 percent. The drug may also be used to reduce the chance that a woman will develop breast cancer in the first place, or to slow the growth of metastatic breast cancer. Tamoxifen works by binding to estrogen receptors on breast cells so that estrogen can't bind and stimulate growth. Learn about the potential side effects, how drug interactions may occur, and how tamoxifen differs from aromatase inhibitors. estrogen-like effects, depending on the particular type of tissue in the body where it acts. It is classified as a selective estrogen receptor modulator (SERM) along with the medication Evista (raloxifene). Tamoxifen is usually not considered beneficial for those who have estrogen or progesterone negative breast cancer. But they do know that some breast cancer cells are sensitive to estrogen. In order to fuel that growth, estrogen must attach itself to those breast cancer cells. Doctors think that tamoxifen stops estrogen from attaching to the cell. No estrogen means no growth for these types of breast cancer cells. Tamoxifen also keeps healthy breast cells from growing and multiplying. That way, it also reduces the number of cells that could become cancer. In a study of more than 13,000 women at high risk for breast cancer, scientists found that women who took tamoxifen for 5 years had fewer breast cancers than women who took a placebo. Newer research suggests that taking the drug for 10 years lowers the risk even more.

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    Tamoxifen, on of the most common hormonal therapy drugs, has been shown to decrease the chance of recurrence in some early stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen is a hormone therapy drug used to treat ER+ breast cancer in pre- and post-menopausal women. Learn about how tamoxifen works and its side effects at Breast Cancer Care. A fact sheet that describes types of hormone therapy, its role in preventing and treating breast cancer, and possible side effects.

    side effect of tamoxifen is blood clots, including deep vein thrombosis (DVT) and pulmonary embolus. In some cases, health care professionals may use the trade name Nolvadex when referring to the generic drug name tamoxifen. This medication is classified as an "anti-estrogen." (For more detail, see "How this drug works" section below). You should seek emergency help and notify your health care provider immediately if you develop sudden chest pain and shortness of breath. Notify your health care provider within 24 hours if you notice that one leg is swollen, red, painful and/or warm to touch and the other is not. A side effect of tamoxifen can be the development of uterine cancer. Women who have not had a hysterectomy should have regular pap smears and gyn examinations. Abnormal vaginal bleeding should be reported to your health care provider. Some types of breast cancer are affected by hormones in the blood. ER-positive and PR-positive breast cancer cells have receptors (proteins) that attach to estrogen, which helps them grow. There are different ways to stop estrogen from attaching to these receptors. Hormone therapy is a form of systemic therapy, meaning it reaches cancer cells almost anywhere in the body and not just in the breast. It's recommended for women with hormone receptor-positive (ER-positive and/or PR-positive) breast cancers, and it does not help women whose tumors are hormone receptor-negative (both ER- and PR-negative). Hormone therapy is often used after surgery (as adjuvant therapy) to help reduce the risk of the cancer coming back. Sometimes it is started before surgery (as neoadjuvant therapy) as well. Hormone therapy can also be used to treat cancer that has come back after treatment or that has spread to other parts of the body.

    Tamoxifen therapy for breast cancer

    Tamoxifen Uses, Side Effects, and More -, Tamoxifen Breast Cancer Care

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  3. Jun 27, 2017. WebMD looks at the use of the drug tamoxifen for treating breast cancer and preventing it in high-risk cases.

    • Tamoxifen for Breast Cancer Treatment and Prevention - WebMD.
    • Hormone Therapy for Breast Cancer Fact Sheet - National Cancer..
    • Tamoxifen therapy in primary breast cancer biology, efficacy, and..

    Tamoxifen for breast cancer treatment is prescribed for 5-10 years. The length of treatment coupled with side effects, such as menopausal symptoms, can make it tough to complete tamoxifen therapy. Dealing with menopausal symptoms related to hormone therapy can be hard. Adjuvant therapy for early-stage breast cancer Research has shown that women who receive at least 5 years of adjuvant therapy with tamoxifen after having surgery for early-stage ER-positive breast cancer have reduced risks of breast cancer recurrence, including a new breast cancer in the other breast, and death at 15 years. Most types of hormone therapy for breast cancer either lower estrogen levels or stop estrogen from acting on breast cancer cells. Drugs that block estrogen receptors. These drugs work by stopping estrogen from stimulating breast cancer cells to grow. Tamoxifen. This drug blocks estrogen receptors on breast cancer cells.

     
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