Just google does low dose naltrexone cause a herxheimer's reaction and I am sure you will find a lot of info. Did you have your med compounded from pure naltrexone powder or from ground up 50 mg Revia/generic equivalent? Here is how it applies to AP https://en.wikipedia.org/wiki/Type_III_hypersensitivity https://chronicillnessrecovery.org/index.php? Hi, Boise CGM- Can you please describe the "awful"? Happy to help if you can provide a few key details. Plaquenil eye oct Plaquenil and blood glucose Plaquenil depression side effects Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. User Reviews for Hydroxychloroquine to treat Undifferentiated Connective Tissue Disease. Also known as Plaquenil, Quineprox. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare. Thanks for the replies,yep,self-induced flare,I think. I couldn't help being a numpty because I felt so good blush I just wondered if Plaquenil made you feel worse rather than better at the start like antibiotics can sometimes. He's excellent, open-minded, and in my opinion quite brilliant - and had the following comment when I asked him about LDN in an email. Kk I've quoted my scleroderma specialist on LDN here before, but will copy and paste it again. Will i feel worse before i feel better on plaquenil Plaquenil.long do I have to wait? DailyStrength, User Reviews for Hydroxychloroquine to treat. - Generic plaquenil side effectsDoes plaquenil help raynaud'sHydroxychloroquine for frontal fibrosing alopeciaChloroquine tonic waterPlaquenil and low dose naltrexone Plaquenil hydroxychloroquine "When first diagnosed with rheumatoid arthritis RA plaquinel worked after a couple weeks. I was in remission soI stopped but Dr upset as he said it was important to keep damage to joints down. Anyway the RA flared and I'm back taking one a day. Hoping to feel better again but seems slow. Hydroxychloroquine User Reviews for Rheumatoid Arthritis.. Can plaquenil make things worse? Lupus Forums at The Lupus Site. LDN. can you feel worse before you get better.. Plaquenil hydroxychloroquine for Systemic Lupus Erythematosus "I've been taking Plaquenil for 6 days now and I already notice a difference in my SLE. I almost feel normal. Before I struggled with fatigue and pain. Since its a mild stimulant it helps with my energy and my body is feeling so much better. Sep 19, 2010 I do remember it took about 8 weeks before I noticed any difference at all. At three months I saw a big difference, and after six months, I am see a lot of difference. Before taking Plaquenil, I could barely walk. Everyone is different, so if a med is making you feel worse, I think you should let your doctor know and consider trying something else. If you definitely cannot take the plaquenil, then you should speak with your rheumy about starting may make you start to feel better. There are other anti-malaria drugs on the market that your rheumy can put you on instead of the plaquenil. But, make sure the he/she is convinced that you are actually allergic to the plaquenil.