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    Clomiphene Citrate is a non-steroidal drug of synthetic origin, classified by its characteristics as an antiestrogen. This drug has received the widest distribution both in medicine and in heavy sports. So, in medical practice, Clomifene is used as a stimulant for ovulation. Having a partial structural similarity with the hormone estrogen, the anti-estrogen Clomifene Citrate can bind to estrogen receptors in the hypothalamus. Due to this there is a large production of gonadotropins FSH and LH, which in turn activates the secretion of the hormone testosterone in the male body and estrogen in the female. Features of the drug The main feature of clomid is that it not only fights excess estradiol in the blood by blocking the receptors of this hormone, but also helps restore the level of luteinizing hormone in the body of men. A lyutenizing hormone is the key link in the production of the male body of its own testosterone. Le prime notizie di un insediamento difensivo nell’ attuale posizione di Carimate si hanno nell’anno 1149 (il Castello fu distrutto nella guerra tra Milano e Como). La costruzione del Castello alla base di quello ora esistente risale al 1345, quando il feudo passò sotto il dominio dei Visconti, signori di Milano. L’edificio fu usato come postazione di villeggiatura e di caccia, ma soprattutto quale fortezza di guardia dell’antica via Regina, strada di comunicazione tra Milano, Como, l’alto Lario e le valli svizzere Ticinesi. Il Castello divenne parte di una rete difensiva a nord di Milano. Si sviluppò un piccolo borgo di personale legato al Castello, case di agricoltori, scuderie. Una quarantina d’anni più tardi Caterina Visconti fece scavare il fossato perimetrale e costruì il ponte levatoio. Dopo il 1402 Il Castello e i beni di Carimate furono concessi in feudo a Giorgio Scaramuzza Visconti già Aicardi, condottiero del duca Filippo Maria Visconti e figlio di Domenico Aicardi di S. La storia racconta che, avendo l’Aicardi padre scoperto una congiura di nobili milanesi alla vita del duca, gli divenne tanto caro da essere insignito del cognome e dell’insegna dei Visconti.

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