Vardenafil was co-marketed by Bayer Pharmaceuticals, Glaxo Smith Kline, and Schering-Plough under the trade name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been returned to Bayer in many markets outside the U. In Italy, Bayer sells vardenafil as Levitra and GSK sells it as Vivanza. Thus, because of European Union trade rules, parallel imports might result in Vivanza sold next to Levitra in the EU. An orally disintegrating form, marketed as Staxyn and Levitra Soft, has been gaining approvals in countries such as the United States inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's. fluconazol pret Levitra (vardenafil), a phosphodiesterase 5 (PDE5) inhibitor, is an oral medication for the treatment of erectile dysfunction (ED). It helps increase blood flow to the penis and may help men with ED get and keep an erection satisfactory for sexual activity. PDE5 inhibitors are a widely accepted and efficacious therapeutic option for the treatment of erectile dysfunction in men, as a result of extensive clinical experience with sildenafil and others. It is available in 2.5 mg, 5 mg, 10 mg, and 20 mg tablets no more than once a day. FDA approval of Levitra was based on four multi-center, double-blind, randomized, placebo controlled, fixed-dose, parallel design trials. The studies enrolled a total of 2431 men with an average age of 57 years. The doses investigated were 5 mg, 10 mg, and 20 mg. 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The mean steady state volume of distribution (Vss) for vardenafil is about 2.5 L/kg, indicating distribution into the tissues. Based on these results vardenafil can be taken with or without food. Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (c GMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (c GMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. 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