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It's important to be aware of how much you drink, side effects and to proceed with caution. Taking Sildenafil with Alcohol, Food, Medications and Drugs. Sildenafil is a compound which affects blood vessel width. This makes it easier for blood to enter the penis, which causes the tissues to expand and harden, thereby facilitating the development of an erection. Sildenafil is a compound which affects blood vessel width. This makes it easier for blood to enter the penis, which causes the tissues to expand and harden, thereby facilitating the development of an erection. According to recent studies, just over half of males between the ages of 40 and 70 are likely to be affected by erectile dysfunction to some degree. Despite the huge number of people affected, there can be no denying that there is still a degree of stigma attached to the condition – it’s often joked about and can be embarrassing to discuss. 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