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    Viagra discovered


    Like most scientists and clinicians in this field, I chose a career developing drugs in the hope of improving people’s lives. I say ‘hope’, because often pharmaceutical research and development is a source of frustration and disappointment. Certainly, we make a continual contribution to scientific and medical knowledge, but our work doesn’t always yield new medicines. Very few of us get to work on compounds that ultimately benefit patients. In two decades of research, I’ve managed to be in the right place at the right time on more than one occasion. But the development program I’ve had the greatest involvement in concerns one of the world’s most famous drugs. Its scientific name is sildenafil citrate, but it’s better known as Viagra. I first came across the project in the late 1980s, when I learned colleagues at Pfizer’s laboratories in Sandwich, a small town on England’s southeast coast, had come up with a hypothesis about selectively blocking an enzyme called PDE5. zoloft side effects reviews Launched in the United States 20 years ago, Viagra has sold in the billions and become an unexpected source of revenue for its maker Pfizer, as well as copycats worldwide. From its serendipitous discovery to its many counterfeit versions, here is a look back at how the world embraced the little blue pill that treats impotence. Discovered by chance At the start of the 1990s, teams at Pfizer experiment with a new drug called Sildenafil used to treat heart conditions. It proves powerless in calming thoracic pain brought on by such infections, but the drug has an unexpected side-effect on men: it causes an erection. The majority of the male volunteers in the experiments also report a significantly improved sex life. Pfizer changes tack, focusing instead on researching male impotence, a problem that affects a third of men over 40. Up to this point the treatment for erectile disfunction has been poor: Only impractical and inefficient options exist, such as mini-suppositories inserted into the urethra or injections in the penis.

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    Dec 12, 2017. Many of the medical inventions we know today were discovered by accident. Take penicillin for example. Sir Alexander Fleming accidentally. rexulti vs abilify Apr 27, 2015. "I was as surprised as anyone when my research on a potential treatment for heart disease revealed a side effect that sparked a sexual health. From Viagra to Valium, the drugs that were discovered by accident From Alexander Fleming onwards, the lives of millions have been transformed and saved by treatments that scientists were not even.

    UK-92,480 was first synthesised in the Sandwich laboratories of Pfizer Ltd, UK in 1989, and resulted from a discovery programme aimed at developing a selective inhibitor of PDE5. The origins of the project that eventually led to the discovery and development of Viagra date from around the mid 1980s. At this time, scientists working at the Pfizer European Research Centre were interested in potential new approaches to the treatment of several cardiovascular diseases. Initially the famous blue pill was developed as a treatment for angina - unfortunately the trials were disappointing and the drug did little to help prevent angina. However, the researchers did notice a surprising side effect – an increased number of erections! “What was amazing about this study was that we saw a restoration of the erectile response. Now we were on to something which could only be described as special,” Chris Wayman, a senior scientist at Pfizer explained, as reported by the BBC. “In many ways you learn as much about your medicine after it’s launched as you knew before,” said Patrick Vallance, head of drug discovery at GSK. Before Viagra was launched in 1998, there was no oral medication for erectile dysfunction. But today Viagra is one of the most prescribed drugs in the world for erectile dysfunction.2.

    Viagra discovered

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    The origins of the project that eventually led to the discovery and development of Viagra date from around the mid 1980s. At this time, scientists working at the. inderal order uk Viagra's was only discovered by accident, it was originally designed 50 years ago to treat adults with depression. The newly discovered properties of Viagra for improving male potency were carefully studied and confirmed from 1993 to 1998, when the medicine finally.

     
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